What are orphan drugs?
The term orphan drug refers to any drug or biological product intended for treatment, prevention or diagnosis of a rare disease. The definition of rare disease varies across countries but typically considers the prevalence of the disease, severity and existence of alternative therapies. As per WHO, a disease is considered rare if it affects ≤ 1 in 1000 population. In Unites states, a condition is rare if it affects fewer than 200,000 people in the country while in European union, it’s for < 1 in 2000 people.
Examples of rare disease include genetic disease, rare cancers., infectious tropical disease and degenerative disease. Oncology products account for greatest number of orphan drug designations.
Why Orphan?
Considering the high cost of drug development and lower patient pool, it becomes unviable for pharmaceutical companies to invest in these rare diseases, thus naming them orphan. In lack of proper diagnostic tools and treatment options, the patient’s suffering widens and poses a challenge for the doctor, society and the Government. To overcome this, the government and several NGOs provide incentives to drug companies to develop and market such drugs. The support is extended by the federal legislature through various research grants, market exclusivity, access to centralized facilities, free scientific advice, tax credits and fee reduction.
Adoption of Orphan drugs
Orphan designation may be granted at any stage of drug development if proper scientific justification is provided for its intended use. Efficacy, safety and quality of the drug should be satisfied to receive market authorization.
USA was the first country to pass orphan drug act in 1983 followed by Japan in 1993, Australia in 1997 and EU in 2000.
It is difficult to understand that countries like India and China being two of the largest in terms of population size still lack the designation of orphan drugs and national legislation for them. It creates a substantial negative impact on patients affected with such diseases.
The rare diseases are estimated to affect 72-96 million people in India. Though rare disease policy was drafted by Indian Government in 2017, it has yet to see the light of the day. The policy is the first major step by the government which recommends genetic counselling, as well as pre-natal and antenatal screening. Indian Council of Medical Research (ICMR) has launched a registry for Indian rare diseases to collect data for policy framing and guide future research. Beyond funding, a more holistic approach and faster implementation is the need of the hour to facilitate the adoption of orphan drugs.
Turacoz Healthcare Solutions takes an initiative to sensitize general population and pharmaceutical companies on the challenges faced by people affected with rare disease and take adequate steps via regular screening to limit such conditions. Turacoz is a medical communication company that provides scientific/medical/ regulatory writing support to the industry and is serving their clients in developing new drug applications, protocol writing for research, and medico marketing support. To get the assistance you can get in touch with us at [email protected]
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Desktop dining has now become a common phenomenon with approximately 65% of working professionals typically having lunch at their desks
October is the “Breast Cancer Awareness Month”. Breast cancer is the second most common cause of death due to cancer
Cardiovascular diseases (CVDs) are a group of disorders of the heart and the blood vessels which include coronary heart disease,
This year marks the 10th World Rabies Day, which has become a global phenomenon since its beginning in the year
Turacoz is a medical communications company providing customized and cost-effective solutions to healthcare and pharma industries. The team of young,
Editing is an important task that is performed by an editor with a good scientific background and good editing skills.
Medical writing is a multidimensional profession which requires creating numerous scientific/non-scientific documents for various phases of a drug life-cycle. Different
What is Triclosan? Triclosan is commonly used as a disinfectant or an antiseptic to reduce and control the bacterial contamination.
Being a medical writer has a lot of allure, particularly if you are having a flexible work schedule, competitive salary
As the cool showers of monsoon bring relief after the torrid summers, the warm humid weather also brings numerous skin
Disturbed sleep and strained red eyes seem to take a back seat as we stand face-to-face with a much more
Viral hepatitis, an inflammatory liver disease is commonly caused by hepatitis A, B, C, D, or E virus. In 2013,
Introduction Dehydration is a condition where free water loss exceeds free water intake. Around 2/3rd of the human body is composed
Turacoz attended 6thAisa- Pacific Pharma congress organized by Omics International on 12th July,2016 at Kuala Lumpur, Malaysia.The aim of the
Humans were designed to move around and stay physically active. However, over the period of time, we evolved technologically and
Diabetes mellitus (DM) has become one of the most challenging health problems in the 21st century. It is a serious
Helen Adams Keller (June 27, 1880 – June 1, 1968) was an American author, political activist, and lecturer. She was
It’s again Ramadan time. Millions of Muslims fast during this period and abstain from eating and drinking. However, two main
Turacoz Healthcare Solutions, a medical communications company will be attending 6th Asia-Pacific Pharma Congress where, Dr. Namrata Singh, director of
Surya Namaskar or sun salutation is a way of saluting sun, the ultimate source of energy and life on earth.
Men’s Health Month is a special awareness period for men’s health observed across the globe. It was passed by Congress
Ramadan is a holy month for Muslims in which consumption of food and drinks, medications, and smoking is forbidden between
Turacoz skill development program conducted a medical writing workshop on publication at Tata memorial hospital, Mumbai on 4th June,2016. The
Turacoz skill development program conducted a seminar on 02 June, 2016 in Center for Faculty Development (Faculty of Pharmacy), Jamia
It’s not just a pain.It’s a complete physical, mental, and emotional assault on your body. -Jamie Wingo May is declared
Turacoz Skill and Development program under the umbrella of Turacoz Healthcare Solutions successfully organized its second Medical Writing workshop in
The month of May is declared as “National Asthma and Allergy Awareness Month” by Asthma and Allergy Foundation of America.
“For Hepatitis, Prevention is the Best Intervention” The month of May is titled as “Hepatitis Awareness Month”, as a proactive
Malaria is a serious life-threatening parasitic disease caused by parasites known as Plasmodium vivax (P.vivax), Plasmodium falciparum (P.falciparum), Plasmodium malariae
Turacoz Healthcare Solutions conducted a medical writing workshop on 16th April, 2016 at Country Inn and suites by Carlson, Bangalore.
Let’s Join Hands to Fight Against Hemophilia Hemophilia is one of the oldest known genetic bleeding disorder which is caused
The Department of Pharmaceuticals (DoP), Government of India, released Uniform Code of Pharmaceuticals Marketing Practices (UCPMP) on 1st January 2015.
Autism is a serious, lifelong developmental disability characterized by considerable impairments in social interactions and communication skills, as well as
World Parkinson’s Disease Day: 11th April, 2016: World Parkinson’s disease day is celebrated every year on 11th April to commemorate
Tuberculosis (TB) is an infectious disease caused by the bacillus Mycobacterium tuberculosis. It usually affects the lungs (pulmonary TB), but
Overview : Colorectal cancer is the abnormal growth of cells in the colon or rectum (parts of the large intestine) that
World Glaucoma Week (March 6-12, 2016) : Be Informed, Be Safe Each year the World Glaucoma Association (WGA) and the
World Kidney Day (WKD) is a joint initiative of the International Society of Nephrology (ISN) and the International Federation of Kidney
Turacoz conducted a seminar on Medical writing as a career for over 125 students with Biotechnology and Life sciences background
Turacoz conducted a Medical writing workshop on February 16th, Tuesday at Radisson Blu GRT, Chennai. It is one of the
Turacoz’s Medical Director, Dr. Namrata Singh was present at the InnoHealth conference held on February 5th at PHD house, Chamber
Turacoz Healthcare Solutions conducted a Medical Writing Workshop in Dubai on 30th January 2016 at Radisson Blu Downtown. The participants
Arab Health Congress is one of the biggest, largest and most extravagant confluence for the pharmaceutical and healthcare professionals. It
February 12 is declared as Sexual and Reproductive Health Awareness Day annually. This day provides an opportunity to raise awareness
Air pollution is the introduction of chemicals, particulate matters or biological materials in air, for a sufficient time that causes
What is a Publication? Publications are a healthcare solution which bridges communication of research conducted to the researchers around the
“Anyone who stops learning is old, whether at twenty or eighty. Anyone who keeps learning stays young. The greatest thing
Practice Flawless English for Good Scientific Writing Knowledge of grammar is one of the keys to writing clearly and credibly.
It is believed that around 1920, a deadly virus crossed species from chimpanzees to humans in Kinshasa (Africa), and led
World AIDS Day, 1 Dec was first declared by the World Health Organization and the United Nations General Assembly in
‘Medical writing’ is a perfect amalgamation of science and art. As a medical writer, one has to maintain a good
As described by the WHO, immunization is the process whereby a person is made immune or resistant to an infectious
Over the years there are many technological advancements that came into light in the treatment of diabetes. These technological advancements
Clinical studies are conducted to test the drugs and medical devices in humans before their approval and availability for the
Reduce your risk today: Eat healthy, Walk more and Weigh less Lifestyle modification for prevention of diabetes mellitus Structured programs
Publishing the results of a study completes the research conducted. As mentioned by EH Miller, “If it was not published,
Knocking out Triple Negative Breast Cancer: A new paradigm in treatment Triple negative breast cancer (TNBC) are the subtypes of
Liver cancer: Treatment Liver cancer treatment is generally based on the stage of disease and the patient response to treatment.
Since 1997, October 20, is observed as the “World Osteoporosis Day” for raising global awareness on the prevention, diagnosis and
Protect yourself from Breast Cancer Over last ten years or so, breast cancer is the most common cancer in most
What is liver cancer or hepatic cancer? Liver is the largest internal organ in the body. It is essential for
“A heart for life” World Heart Day (sponsored by World Heart Federation) was founded in 2000, a biggest intervention against
September is Prostate Cancer Awareness month Globally, prostate cancer is the second most frequently diagnosed cancer in men and the
World contraception day (WCD) was first conceived in the year 2007 by 10 international family planning organizations in order to
Understanding environmental health The International Federation of Environmental Health, better known by its acronym IFEH, works to impart knowledge regarding
Newborn screening test (also known as Guthrie test) is one of the successful innovations in the modern era. It is
Fast Facts 2 A genetic disease, resulting from environmental (gluten) and genetic (HLA and non-HLA genes) factors. Estimated 1 %
Attempting Suicide and having suicidal tendency are the most extreme form of self-harming behaviour exhibited by humans. Centre for Disease
Psoriasis is not all of you, it is just a part of you like everything else Psoriasis is generally classified
Dr. Namrata’s mantra for life is “nothing is impossible”. Her experience of 10 years as a pediatrician and 9 years
Today on Organ Donation day, Turacoz team members pledge their organs for a noble cause and want to contribute to
“Once you choose hope, anything’s possible.” Christopher Reeve Sarcoma, may be defined as “a malignant tumor of connective or other
The 5 tips for desktop workers are absolutely essential to maintain and good health and have a long innings professionally.
Ramadan is a lunar based fasting month for Muslims. Muslims who fast during this time should refrain from eating, drinking,
Sarcomas are the tumors originating from mesenchyme and contribute to about 20% of all pediatric solid malignant cancers and less
Yoga has been an integral part of India since Indus Saraswati civilization for about 5000 years now. With time the
Asthma is a worldwide disease affecting an estimated 300 million individuals globally. Some authors also reported prevalence of Asthma as
“In three words I can sum up everything I’ve learned about life: it goes on.” ― Robert Frost Hemophilia- a
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